If airbus design life and inspection schedules are based on a say 75% packs on and 25% pack off take-offs, and operators ask us to make 100% packs off take-offs, there is the seed of a doubt re this as a lifetime procedure for these aircraft.
Don't forget bleed air extraction during take off (if packs ON) and thus a higher thrust rating needed for take off and thus higher fuel consumption, higher EGT and higher engine wear etc.
Pilots with ear problems can be replaced by cheaper P4T/P2F pilots, but engines, maintenance and fuel still cost money.