Just as long as you don't have any additional problems to cope with then trim the system, as best you can, for maximum passenger comfort. However, if you know that you're going to be descending into a very busy ATC environment and you're not able to (nor shouldn't) give it your maximum attention... set the system to depressurise at a sensible height above the airport elevation, The last couple of thousand feet (unpressurised) isn't going to give you, or your pax, any drama. Or, weld a third seat into the flight deck and strap a FE into it!