I am fortunate to fly in an environment where hand flying is encouraged and practiced on the line.
I have never done a Smoke, Fire or Fumes scenario. It was not part of the TR syllabus. 2 years on the line now, B737 F/O. Would need a creative TRE, but should be doable no?
An unreliable airspeed departure profile, airwork/return, and approach in IMC would also be a confidence boost.