I mostly fly this thing (330) on the approach without autothrust. And on many occasions without AP and FD. And I never had any problem. In fact I control speed better than AT, as I don't let it go all the way down to VLS (as AT does) and then apply too much thrust to recover. It's always much smoother.
Old habbits (747) die hard
She has only two thrust levers, not four. Piece of cake
