Mary Meagher
I am not sure whether Clarence built Zodiac CH 601, although it is said that Chris Heintz designed the original Zodiac.
And yes, Clarence Andrews died in an airplane he had built, Cassutt was the name.
In his Eulogy, it was stated that he was an accomplished pilot and aircraft builder. He built two airplanes and that he was a successful Mechanical Engineer who graduated from Auburn and also worked with US Air Force from 1951 to 1955 as a crewman, where he developed his love for flying.