When we first started flying the VC10K to the USA, we had to use the RAFAIR callsign, which caused great difficulty for the mononeuronic colonials. They called us 'Royal Air', 'Rough Air', 'Romeo Romeo Romeo' and various other perversions. Eventually a commonsense brain cell kicked in and all VC10s then used 'ASCOT' on overseas trips.
I remember the 'Mike plus 4' callsigns such as MBGFK or whatever. If I recall correctly, 45/58 Hunter Wing were once allocated Mike Alfa Foxtrot India Alfa for a trip to Denmark. As their boss said at the time "It's a good job we're not flying to Sicily!"...