I reckon it will be a pretty decent sector actually. In body clock terms for the QF1 it will be about a 7am (based on EST) report for an 8.05 am departure. Probably a 5.30ish am wake-up. Could be a lot worse.
Arrives in London about 4pm body clock.
The southbound sector ex LHR would be much worse for mine - even with a couple of days off. Anyway, the odds are that EK will be doing it soon anyway.