which version of windows are you running?
Had similar problems with my son's netbook a couple of years ago and the problem was because the Lego software wouldn't work on the installed version of Win7
The netbook came with Windows 7 Starter - on which you can't install the .NET components required by the Lego software. I had to upgrade the version of Windows
Also seem to remember that the software had to be patched with downloads from the support site