Runway
SOE
One at the moment - Thomson Cancun. Stops at Manchester outbound and as it is not listed on Thomson from Manchester I assume it is not picking up pax.
BHX-Vancouver weekly summer only (linking two Sikh expat destinations) is a possible route as is Vegas. I don't believe either would be possible direct at present although I agree three flights a week (Cancun, Vancouver, Vegas) is hardly a business case taken in isolation but who knows what the future holds especially looking East.
Full length use
The other environmental aspect is if the full length off 33 is used then the noise footprint over Birmingham will be reduced a little bit. I assume this will not be enforced by the lack of spin.
Planeaddict Viewing area - unless there is money in it then BHX won't be interested. It will have to be a private venture and that is a tough ask at present
San Francisco - No. Even if someone started it then it would not last beyond a season.
Pete