I think the O/P was asking about
safest seat, rather than that which is the best in the rare even that the aircraft makes it safely to destination.
If that was the question, I think that the historical evidence points to being in the last few rows of Y. But, for the most part, you have to watch the aircraft coming down and then walk down what is left of the aisle to see who is alive. Then yank them out of it and get buckled in.
