A thought or two, if I may -
(a) intentional launch with a U/S per MEL means that the conditions pertaining to the MEL address a presumed consequent failure ie it's a quasi-"normal" operation. This is one of the reasons that such schedules require multidisciplinary input for the decision process ... the line item sets out to maintain something approximating the original Design Standards requirements ... if the decision is set up by a single discipline, the risk is that matters required to be considered but outside that discipline may be missed.
(b) in-flight U/S is the realm of QRH actions and effecting a safe recovery in the particular set of circumstances. One is well counselled to consider the MEL words as a useful input to the decision process but the intentional launch considerations are not relevant.