A single straight line as direct as possible for initial planning, then modified with a slight track deviation to a half way point for fuel. Thirds or quarters if payload/range doesn't allow a half way stop. Even before GPS that's how I got about the place.
BTW, Google Earth/Maps or Great Circle Mapper can help with this. You can start with the non-stop and then add additional routes with stops to compare distances. Easier than laying out WACs on the floor!
Last edited by Tinstaafl; 3rd Nov 2012 at 17:56.