Depends on the comms setup in the aircraft. If it uses a standard GA-type radio / intercom then a GA-type headset should be fine in an enclosed 3-axis microlight. If the aircraft uses a handheld radio with a proprietary intercom (usually Lynx, Flycom or Microavionics) then you will need a headset designed to work with the proprietary intercom.
That said, there are adapters available to make a GA-type headset work with the proprietary gear and vice-versa .......