As with anything in life, nothing is 100% safe. You have a much higher chance of being killed in an auto accident than a plane accident. Your lifetime chance of dying in an airplane accident is 1 in 20,000. For an auto accident it's 1 in 100.
Among the other things you might die of before dying in an airplane accident are:
Drowning, eletrocution, fire or smoke, falling down, suicide, stroke, cancer and heart disease.