No operator, in their right mind, would base an aircraft at Valley with it's social hours only opening times and other restrictions.
It would be, quite literally, Monday to Friday dayliight only operations, incur a delay and end up diverting to somewhere like LPL, aircraft and crew out of position for the next morning thus another day of delayed operations.
Then, to make such an operation viable, strip the seats out and operate night freight ... except that one can't because the airfield is closed.
Only way any operator could make it pay would be to charge premium fares or, via WAG, be heavily subsidised by the British taxpayers.