Nope. ND simply works out current distance to waypoint at current G/S and gives you an ETA. Simple slide rule stuff.
FMGEC Is a bit smarter than that, it calculates the ETA using your Selected/managed profile ( CLB CRZ DES ) and uses the forecast winds you've entered PLUS it blends in actual winds to arrive at accurate ETA predictions for all down route waypoints including Dest.
Hence over long sectors ( 450 miles ) the ND and FMGEC Flt Pln ETA's for your active waypoint may be a lot different due to the current wind being different to the forecast up ahead of you.
Same on the Boeing's I've flown.