Thats only on some types.
Others as the airframe gets older and more bent you have to retrim it every time you change speed and or power setting or configuration
normal for me its rough elevator trim, then trim rudder, then aileron, then fine trim elevator. Once in the cruise and power set rudder trim for max ground speed off the gps, aileron trim, finally the elevator. After which you can fly hands off for extended periods in still conditions.
As soon as you start to decend your back on it again.
It sounds all very labour intensive but quite quickly it becomes second nature like changing gear in the car and your hands just do it without commiting much brain power.
The trimming art is what makes a pilot on a manual twin. Once you crack it the work load drops off and you can leave the aircraft to do the flying and you only have to point it in the right direction and not annoy it which would then take it out of trim and mean you would have to fly it.