Aileron trim is generally a set and forget type thing. You might tweak one way or another to get it flying nicely after take-off but it doesn't need anything after that, and as long as it is not reset on the ground it won't need changing for a subsequent flight. Rudder trim, on the other hand, needs constant attention. Any change in power requires a change in rudder trim. It is not necessary to set anything other than neutral for take-off though. I'd suspect that someone who is changing aileron trim a lot should probably be adjusting the rudder trim instead.
Many twins don't even have an aileron trim.