Many airlines don't "require" 1000 turbine PIC - if you've a blood relative on the hiring board.
Many airlines don't "require" multi engine turbine - if you're coming out of the military off of a posting on the F-16.
Many airlines don't "require" a college degree - if there's nobody with your qualifications available who has one. At the moment, there's no shortage of pilots with a full set of education credentials and thousands of hours of flight time. And as already pointed out, being hired at a regional airline without a four-year degree just gives you a land mine at the major hiring level that you're not likely to dodge.
There are some success stories of people finishing up their college online after they get a flying job, but not having a degree at all ensures a second-tier CV in the U.S. and abroad.