As a passenger, I have taken off in a A300 on Easter Airlines (showing my age!) from FLL! I was very concerned as we started the take off roll and figured the cockpit crew would get the take off warning and abort! NOPE! We climbed out fast and had no problems so I assume you can do it!
I worked for US Airways and know that our former Fokker 100's could and did take off with no flaps!
Personally! I like flaps!