I don't know anything about these planes but you need to carefully define your mission profile.
No use flying around in a big thirsty twin unless you need the extras which is gives you
- a 2nd motor (an emotional factor)
- more payload
- anything else?
All the other stuff you can get in a single, potentially.
If you want long distance and a high despatch rate, a PA46 is hard to beat and a Jetprop will beat the opposition into dust.
A big piston twin will just eat your money so you need to be sure. You mention Europe... had a look recently at landing fees and avgas pricing over here?
Not to mention Eurocontrol route charges.