The Cumulogranite, you mean this might happen?:
Incidents and Accidents
Of course you don't balance engines with removable items (fuel,passengers or cargo), you design the structure to balance when empty. In the incident in the above link, the fin tank was still full, causing the aircraft to tip up.
There is something to be said for this layout (Tupolev TU-22 Blinder), as there is less assymetric thrust in single engined flight, so less rudder drag and therefore less power required to overcome it:
The engine change crew won't thank the designer though...