During the 1970's I remember watching an EC121 on a flat 8000 ft runway trying to get airborne.
First 5500 ft of runway with a slight uphill slope. Last 2500 ft had a fairly sharp downhill slope.
Average runway slope was zero. Great until the EC 121, whilst accelerating uphill, had an engine fail late in the take off roll and then tried to stop going down hill, and inevitably into the overrun.
Guess after all it is still has a bit of chance associated with it.