Best bang for the twin buck these days? A Cessna P337 Skymaster or a pressurised Aerostar (601P). The Aerostar will outperform any piston anywhere when it comes to speed. Or if you throttle back, be the highest MPG twin you can own. Yeah, it's a hotrod, but built like a brick house. They have few AD's and have never had an inflight breakup.
Here's a gorgeous example:
Coats and Evans P.C. - Flight Operations