I just fold and refold en-route as required.
Mind you, I'm not using laminated maps (they are a bitch to fold) but the paper Jeppesen VFR+GPS ones.
The route line is just drawn with a lead pencil, and for all other information I keep a plog, with headings, distances and ETE/ETA/ATA. I hate scribbling numbers on the map itself since there's never enough room to include both the heading and ETE.