A twin motorcycle has a rolling couple caused by the offset of the crankshaft as each cylinder moves out / back together. So if a difference of a couple of inches creates a couple in a motorcyle engine, it will also create a couple when the MRG and TRG centers are not in a single plane.
The influence of that couple might not be large, and it does not account for tail rotor drift; but my understanding is that it will be there.