Oldflyer... I just wanted to clarify that you're quoting references for Normal, Utility, Aerobatic and Commuter category airplanes in the US and Canada. For Transport category airplanes in US and Canada the regulations are slightly different:
Part V - Airworthiness Manual Chapter 525 - Transport Category Aeroplanes - Transport Canada
If you feel like reading directly from the FARs, the reference is the same except no 5 in front, ie: 25.107.
Like some others have stated, V2 is NOT the same as VYSE. The 'safety' part in 'takeoff safety speed' relates to certain criteria that has to be met for the V2 speed. It does not mean that you will have the best
performance at that speed while single engine. That is what VYSE is for - or VXSE.