Joselu, to answer the question you asked (as opposed to the one you didn't!) if you don't want layovers on the A330 they are easy to avoid most of the time. It is getting them that tends to be a problem for most people! You will be doing a lot of night flying though, if that makes any difference.
If at some point you end up on the A380 (and you may not have a choice in this) it will be a very different story, but you will have more days off.