I fly all the current 777 airframes including the 777F, and to be honest I do it no differently purely because that's the way the guys that own the trainset want it done. That being said, flying the freighter is a bit more informal with more T-Shirts and slippers on show.
I recently flew an empty 777F from the antipodes to a well known southeast Asian trading port, empty, and when I mean empty, I mean landing within 1 tonne of the MLW of 154T or so. With a moderate 15-20kts of wind, a bit of mechanical turbulence off terrain and the considerable residual thrust of the GE-90-110's, the old girl was a handful....and required a good chunk of crossed controls to dump enough lift so I could plant it where I wanted it..even at F25
