I hamd fly to TOC or at least until at climb speed above FL100 regularly. I'm often asked if I have a sim check coming up. On the way down, on a 4 sector day I try to hand fly from 3/4000 ft on base leg at least once, depending on fatigue / weather etc. Noramlly it will all be flight director but if good VMC I'll fly raw data ILS or perhaps a visual.
I find hand flying stimulates the brain in a different way from monitoring the autopilot and makes me feel 'sharper'.