Now pleasantly back on the pax fleet and no longer making my own coffee in the middle of the night, I would have to agree with most here saying that pax comfort comes first and in the freight world, unless it's time to eat dinner, moderate chop is tolerated for a much longer time.
As for flying the aircraft itself differently, not at all. You'll still end up in the office explaining yourself when the aircraft rats you out for unacceptable flying technique.
FR8