Not about flying differently but dressing differently. On the freighter we tend to fly in jerseys and flip flops, love the informality, though I do put on my shoes prior to landing, would hate to evacuate in slippers. The food is more basic but the loadies are better cooks, and I make my own coffee.
Started as a freight dog and after many years as a pax pilot am enjoying the hell out of flying a A330F for an airline if I mentioned its name PPrune would ban me.