Absolutely no difference. I have no more desire to upset a box full of dangerous goods than I ever had to spill Lord Posh's G & T in first class
Very valid point about that HazMat. Flying all-cargo ac you're likely to carry a LOT more of that stuff. Sure, it's checked and re-checked and tied down and all that, but Lord's whatchmacallit drink-soiled pants are lot easier to deal with than the contents of a busted HazMat package sloshing around in the cargo hold...