I guess I'm luckier than most, but I wear contacts (for medium level short sightedness!) and very rarely have any issues with them, GA, commercial (as a passenger), or otherwise. In fact, 99% of the time I'm not even conscious I'm wearing them.
I wear the type that you stick in then forget about for 30 days (aside from taking them odd for a clean once every couple of weeks), even over night. The key is getting them in cleanly and quickly first time, then once in they're fine. Putting them in is no issue at all, you very quickly get used to the sensation of doing so, which really isn't much of a big deal.
On a commercial plane, they can get a tiny bit dry over an extended period of time, although this really applies to anywhere air conditioned. It's never been bad enough for me to feel the need to put drops in, so can't be all bad. For GA I have no issues at all, 20/20 vision all round and makes it much easier to take sunglasses on and off when required.