I'm a very docile pilot, but I've had a couple of people go sickie on me in the air. Thank goodness for my autopilot! An instructor once tipped me off to keep a bag in my kneeboard when taking first timers up.
My first passenger was my father.
He wasn't sick, but he told me after landing that he'd spent the whole flight worrying about being sick.
Because I hadn't told him where to find the sick bag, so he didn't even know that there was one.
This
is now part of my passenger briefing!