Hello Hal, do you read
Your destination has an unforecast crosswind, you will have to program
yourself to do a circling approach onto the shorter runway without
an approach aid or guidance.
Firstly, the flight plan will have the same alternative destinations as current, with the same fuel considerations for missed approaches, etc. Secondly, the decision whether to make a crosswind landing on alternate runway will be made by remote pilots with the same situational awareness as per current pilots aboard the aircraft.
Remote pilots will also be available to make critical decisions such as whether to return or land on the Hudson river if a double engine failure occurs post V1 on a JFK takeoff.
From an economic perspective, pilotless UAV aircraft are inevitable, especially with freight aircraft that wouldn't require the resiliency and crash protection of manned aircraft. If we have the technology to to unmanned freight trips to a space station orbiting at 24,000 km/h then we can certainly do it on here on planet Earth to fixed runways at known locations.