Programmable flight into aircraft so in the event of loss of ground communications it flights itself to destination or alternate with options in case of weather etc.
Unpalatable as it seems, I see it as a reality with time frame described.
I can almost envisage a scenario in the future when aircraft have no cockpit, no windows and Airline crew on board amount to one or two people who check that everybody is buckled in.
Fact is that they can end a cargo vehicle to Space Station without a pilot.