I was diagnosed with AS about 10 years ago. Not an issue at all. You just need to face up to taking the drugs regularly and keeping exercised. Pilates is good. NSAID's are good, but depending on country will get the attention of your aviation medical examiner because of the cardiac and stomach risk. TNF - alfa inhibitors are better and safer if they work for you. Find a good rheumatologist that you like. You are going to have a long term relationship with him.