I find taxiing in the simulators to be an atrocious representation of reality. I think it's mostly to do with the way the visibility is programmed, but while I can comfortably see all lights and signs in reality, in the simulator I often cannot, and when I do, since it's a two dimensional wrap around screen, any intersection with multiple outlets on the same side get's confusing quickly.
Also, having never gone down the wrong strip of pavement in reality, I quickly headed right into a ramp area in a simulator when cleared to the runway, though, I realized my predicament rather quickly.
I think reasonable instructors understand the limitations of the boxes and judge accordingly.