Alaska Airlines has been using the iPad as their EFB since Jun, 2010 or 2011.
Alaska, AA and UAL (and Republic, the largest regional airline provider) are all going with the iPad.
Atlas, and reportedly DAL (Delta) are going with an Android based tablet.
I am not sure what the paper Jepps situation is. I do know that many "business" type jet operations already operate without any paper of any kind in the cockpit. The Emirates pilots that flew me in 2010 said EK was going totally paperless. Atlas is also planning on going totally paperless.
I have heard that some aviation organizations were required (by the FAA) to have one set of paper Jepps on the plane, in addition to the two EFBs, at least for a certain time period.
Also, the iPad has been through all the standard physical testing (depressurization, cold, hot, etc.) by the FAA before it was approved as an EFB.
cliff
BAH