Yes but...
The C441 has a pretty small door for air ambulance work. I don't think it would be easy to get a litter patient through that door, and I cannot remember if I ever did. I loved flying it, though.
The nose gear is kind of puny and the props don't much like loose surfaces, but what a performer it is! It would true out close to 300 knots with -10 engines, at ISA +15. That was with those trick 4-blade propellers; I think they are part of the kit.
If you can get a King Air for cheap, well...
There's no question that turbine engines beat piston engines all around. The thought of lining up on a short strip at a high density altitude, with a full load... you would really want to bet the farm on piston engines? No, not really, although most of us have done that quite happily, for a while at least.
I can think of at least three fatal accidents in piston twins that were EFATO, two Navajos and a C404.