I would think that the best way to calculate it would be to work out the fuel burned and divide it by the zero fuel weight (Is the payload = to the zero fuel weight of the a/c or the total fuel on burned is included?).
Given the data you have, and the most common definition of efficiency -- (fuel burned) / (payload * distance) [kg/tonne-km or kg/passenger-km] -- the answer is NO on both counts.
First, to get fuel burned, you need fuel on board at startup AT THE ORIGIN and fuel on board at shutdown AT THE DESTINATION ("block fuel"). Fuel uplift will NOT give you an accurate figure, since it is a function of the fuel remaining after the PREVIOUS flight and the fuel required for the current flight.
Zero fuel weight includes the weight of the airplane AND the payload. Payload is the ONLY thing that "counts" in the commercial world.