My bets for future American destinations (based on no inside information):
Boston (KBOS)
Washington Dulles (KIAD)
Chicago (KORD)
Atlanta (KATL)
Seattle (KSEA)
Las Vegas (KLAS)
Miami (KMIA)
Of course, EK just added Dallas Ft. Worth (KDFW) - that would be a great layover for steak lovers - try the cattle yards (not exact name) in old Ft. Worth - AWESOME food.
Again, the EK CEO has stated in recent articles that all US destinations would "eventually" be served by A380s... So, future US destinations would likely need to accomodate A380s and not all can do so presently. I know KIAD and KMIA currently do accomodate A380s for Air France and Lufthansa. Perhaps 777s would be used initially to build traffic for eventual A380s. Of course, this is all pure speculation until something happens...