They've not been tried out very often in a non permissive environment,
Maybe not recently, but Vietnam wasn't exactly what one might call a permissive environment (ok, so its from Wiki, but its mentioned elsewhere):
...and the Iranians having their way with a fancy American drone is another data point
Is there any real evidence yet that the Iranians did more than use a jammer (which may or may not have actually had any effect), and got lucky when the RQ-170 had a flameout in when in return home mode?