Errrr...runways with offset localizers will not be designated for LVP operations. Also, the lightings need to better or at least equal of Cat I standards.
Gerago,
We are talking about departure low viz for rwy 22R, not landing. If the CL and HIRL is working, it is good for 5. It has nothing to do with an off set LOC, yet the LS button would be affected by an offset and therefore is irrelevant to push and check LS on departure. Not many guys would ever check the ILS course and compare to runway track. We all look at taxi charts, minimums, and SIDS, generally and read about any other relevant airport procedures and follow the SOP with taxi procedures, in general.
LVP can be in force, and the said runway can handle low viz take-off, but not landing of course, so don't push the LS button on line up.