Seeing as how no Navy has EVER had to face an attack by anywhere near 40 missiles at the same time in the missile age I think that T45 with its 48 Sea Vipers will be fine. Isn't that more missiles than the Argentines have fast jets?
No Navy ever lost a ship to an airplane until the 1st one.........
Just because something hasn't been done doesn't mean it will never be done.
USS Cole lost out to something a lot less than a missile.