Yes.... er... No.
Is this a trick question?
A better question might be "Are there any similarities?"
There are probably tens of thousands of differences between the two aircraft, depending on how deeply you want to go into the matter. Would you have expected otherwise, coming from two different manufacturers?
What exactly are we talking about here? Fuel feed, fuel capacity, tank configuration, fuel feed logic, fuel jettison logic/control, fuel pump/valve control, type/number/location of fuel quantity sensing devices, type of valves, fuel system cockpit displays, type of cockpit warnings relating to fuel system anomalies, etc.
BTW, I have a 300 page book on the 747-400 fuel system (simplified version)... and that's only for one type of 747-400. There are many 747-400 fuel config differences depending on engine type and airplane configuration (Does the 747-400 you have in mind have a Horizontal Stabilizer Tank or Auxilliary Tank?).
I think most of us wouldn't even know where to begin answering your question. Perhaps you could help us by telling us why you are asking? (Is the question desktop simulator related?).
Q.