Maybe more info would elicit a reply.
I have noticed the same problem when using an external hard drive console. Some HDDs work OK but some do not. I don't know if it is because of what is on the drives or the size of them, but generally the smaller drives work and the bigger ones do not. What happens is that Windows Explorer stops responding, a lot of programs stop working, some screens go grey (or they seem to have an overlay of grey) and Word does not work when the drives are plugged into the USB port. Those programs that do work do so very slowly.
As soon as I pull the USB everything works again.
This is stopping me from doing any backups, which is annoying since I have almost lost the original drives in a recent RAID incident and want to be prepared for when it finally goes mammaries skyward.