For example, The 747 -1/2/300/SP (Classics) lock the outboard ailerons out when the flaps are extended. The 747-400 locks them out at 238 knots.
Boeings tend to have inboard ailerons to prevent wing twisting. Other designs had stiffer wings, others geared the ailerons so thy deflect less at speed and some deploy a small amount of spoiler to assist roll.
The Airbus Fly By Wire types are different. When the pilot moves the side stick, he/she are demanding a roll rate and the computers move the ailerons/spoilers accordingly.