Shall I hazard a prediction?
At some point, a 330 min ETOPS (or even 220) will go in with loss of all persons. ETOPS will get restricted during the investigation. Depending on the outcome, it might even be restricted a bit longer.
But, ETOPS (or any other acronym) is the only game in the world and it WILL continue. Inevitably, this being a human enterprise, some people will die.
Your predictions are likley to be true but it is more likely that it will be a 4 engine aircraft.
However, even with that, single data points are not significant to statistical analyis and regardless of the cause, the mechanical causal factors will be considered (are they segment time related) rather than I-told-you-so predictions.